Endocrine Abstracts

Background: Metformin is one of the first line drugs used to treat type 2 diabetes mellitus, even though there are still many gaps on how exactly metformin works. This is due to many years of research using various concentrations of metformin and also, not considering the conditional effect that glucose can have in its action.Objectives: Study the effect of different concentrations of metformin and glucose in cell culture.Methods: ...

Influence of Diabesity in the visceral adipose tissue miRNA expression profile.Background: The term diabesity arose in 2001 to refer to the coexistence of obesity (OB) and type 2 diabetes (T2D). It is estimated that 89% of adults diagnosed with T2D have a BMI greater than 25 kg/m2, and of them, 45% are obese. However, the mechanisms because why some obese patients develop T2D and other do not, are still unclear.Objective...

Background: the treatment of individuals with type 1 diabetes (T1D) has significantly evolved in recent years. Therefore, with the aim of achieving glycaemic targets to prevent or slow down the progression of the disease and its complications, hybrid closed-loop systems (AID) have been developed. These systems integrate three components: a continuous real-time glucose monitor, a control algorithm and an insulin pump. The objective of this study is to analyse the glycaemic and ...